Therapeutic Category: Cholesterol-lowering agent
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Atorvastatin, a synthetic cholesterol-lowering agent, is a medicine called (3 hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitor. This enzyme is involved in cholesterol biosynthesis by catalyzing the conversion reaction of HMG-CoA to mevalonate. The fuction of lowering the amount of cholesterol leads to the result in clearing the LDP (low-density lipoprotein) cholesterol in the blood by increased LDL receptors. The calcium salt of atorvastatin is used in the treatment of primary hypercholesterolema and dyslipidemia. It is a white to off-white crystalline powder; slightly soluble in water (insoluble in aqueous solutions of pH 4 or below); soluble in methanol, dimethyl sulfoxide; administered orally. The chemical designation is [R-(R',R')]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-( 1-methylethyl)-3-phenyl-4 [(phenylamino) carbonyl]- lH-pyrrole-1-heptanoic acid, calcium salt (2:1).