Hyaluronan (also called hyaluronic acid or hyaluronate) is an anionic, nonsulfated
glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Hyaluronan is a polymer of disaccharides, themselves composed of D-glucuronic acid and D-N-acetylglucosamine, linked via alternating beta-1,4 and beta-1,3glycosidic bonds. It can be obtained by extracting from cockscomb or through microorganism fermentatio.
Hyaluronan through the oral administration after the digestion absorption, increases in vivo hyaluronan synthesis the precursor, causes in the skin and other organization's hyaluronan resultant quantity increases, thusenables the skin the water retention property to increase,rich elasticity, wrinkle reduction.
Medical applications: Hyaluronan could be used in eye surgery, such as corneal transplantation, cataract surgery,glaucoma surgery, and surgery to repair retinal detachment. Hyaluronan can also be used to treat osteoarthritis of the knee. They are administered as a course of injections into the knee joint, which are believed to supplement the viscosity of thejoint fluid, thereby lubricating the joint, cushioning the joint, and producing an analgesic effect.Hyaluronan has also been used in the synthesis of biological scaffolds for wound-healing applications. These scaffolds typically have proteins such as fibronectin attached to the hyaluronan to facilitate cell migration into the wound. Hyaluronan is also used in anti-adhesive products, which are widely used in pelvic and abdominal surgery to prevent postoperative adhesions.
Hyaluronan has outstanding moisture keeping ability, thus called Natural Moisturing Factor in the world. Hyaluronan is a common ingredient in skin-care products, which can be used as a very effective topical humectant.In 2003, the FDA approved hyaluronan injections for filling soft tissue defects, which can be used for facial wrinkles, lip augmentation, reduction of folds and wrinkles,and removal of scars.
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