Comestic grade Alpha Lipoic Acid

FOB Price: US $100 - 120 / Kilogram Get Latest Price
Min.Order Quantity: 1 Kilogram/Kilograms
Supply Ability: 100 Kilogram/Kilograms per Month
Port: China main port
Payment Terms: T/T,Western Union
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Quick Details

CAS No.:
1077-28-7
MF:
C8H14O2S2
Place of Origin:
Shaanxi China (Mainland)
Purity:
99%
Classification:
General Reagents
Brand Name:
LTB

Packaging & Delivery

Packaging Detail: plastic bag and drum for export grade
Delivery Detail: within 1 day

Specifications

Alpha Lipoic Acid
CAS Number: 1077-28-7
Molecular Formula: C8H14O2S2
Molecular Weight: 206.33
Purity:99.0%-101.0%

Alpha Lipoic Acid is found in almost all foods, but slightly more so in kidney, heart, liver, spinach, broccoli, and yeast extract.

Lipoic acid is an organosulfur compound, one enantiomer of which is an essential cofactor for many enzyme complexes. This yellow solid is a carboxylic acid and features a cyclic disulfide, or ditholane ring, functional group. The R-enantiomer is biosynthesized and used as a cofactor. It is essential for aerobic life and is a common dietary supplement.
Dihydrolipoic acid is the reduced form which is mostly how the sulfurs exist intracellularly. "Lipoate" is the conjugate base of lipoic acid, and this is the form carboxylic acids take at physiological conditions. So free lipoic acid inside the cell could correctly be called dihydrolipoate. Most intracellular lipoic acid is not free, because it is made and attached to the enzyme complexes that use it. As a cofactor it is covalently bound via and amide bond to a specific lysine residue of lipoyl domains.
One of the most visible roles of lipoic acid is as a cofactor in aerobic metabolism, specifically the pyruvate dehydrogenase complex. Lipoate participates in transfer of acyl or methylamine groups in 2-oxoacid dehydrogenases (2-OADH) and glycine cleavage complexes (GCV), respectively.
Use as a dietary supplement:
Since the early 1990s lipoic acid has been consumed as a dietary supplement, typical doses are 100–200 mg/day.
A chronic/carcinogenicity study in rats reported that racemic lipoic acid was found to be non-carcinogenic and did not show any evidence of target organ toxicity.
Antioxidant:
Lipoic acid was first postulated to be an effective antioxidant when it was found it prevented the symptoms of vitamin C and vitamin E deficiency. It is able to scavenge reactive species in vitro, though there is little or no evidence that this actually occurs in vivo. The relatively good scavenging activity of lipoic acid is due to the strained conformation of the 5-membered ring in the intramolecular disulfide. In cells, lipoic acid can theoretically be reduced to dihydrolipoic acid (ΔE= -0.288), though significant quantities of dihydrolipoic acid derived from orally-ingested lipoic acid have never been demonstrated. Dihydrolipoic acid is able to regenerate (reduce) antioxidants, such as glutathione, vitamin C and vitamin E. Recent findings suggest that lipoic acid curative effects is due to modulation of regulation in eukaryotes. This occurs due to lipoic acid acting as an oxidant, not a reductant.
Disease Treatment:
Lipoic acid has been shown in cell culture experiments to increase cellular uptake of glucose by recruiting the glucose transporter GLUT4 to the cell membrane, suggesting its use in diabetes. Studies of rat aging have suggested that the use of L-carnitine and lipoic acid results in improved memory performance and delayed structural mitochondrial decay. As a result, it may be helpful for people with Alzheimer's disease or Parkinson's disease.
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Changzhou Longterm Biotechnology Co., Ltd. is a research-driven and customer-focused company with head office located in Changzhou, Jiangsu, China, and sales office located in Xi'an, Shaanxi, China.

As a professional manufacturing company, we discover, develop and commercialize innovative active pharmaceutical ingredients (APIs), cosmetic ingredients and dietary supplements, both synthetical and natural, which enable people to live to the greatest potential, to see more clearly, move more ... View detail

Basic Information

Product/Service (We Sell): Noopept,custom-made,polypeptide  
Number of Employees: 101 - 200 People  

Trade & Market

Main Markets: South Asia
Northern Europe
Central America
Western Europe
Eastern Asia
Mid East
Oceania
Africa
Southeast Asia
Eastern Europe
South America
North America
Total Annual Sales Volume: US$50 Million - US$100 Million  
Export Percentage: 61% - 70%  

Factory Information

Factory Size (Sq.meters): 5,000-10,000 square meters  
Factory Location: 291 Li Hua North Road, Tianning Dist.  
Number of Production Lines: 5  
Number of R&D Staff: 5 - 10 People  
Number of QC Staff: Less than 5 People  
Management Certification: ISO9001   ISO14001  
Contract Manufacturing: OEM Service Offered   Design Service Offered  

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China (Mainland) | Manufacturer, Trading Company | Contact Details
Experience: Established 2009

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Ms. Ping Wang
Ms. Ping Wang:
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