ELEUTHEROSIDE E Chemical Name: (2R,3S,4R,5R,6S)-2-[4-[4-[3,5-Dimethoxy-4-[(2S,3R,4S,5S,6R)-3,4,5- trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-1,3,3a,4,6,6a-hexahydrofuro[4,3-c]furan-1-yl]-2,6-dimethoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol CAS No.: 39432-56-9 Molecular Formula: C34H46O18 Mol. Wt.: 742.72 Molecular Structure:
Eleutherococcus senticosus is a species of small, woody shrub in the family Araliaceae native to Northeastern Asia. It is commonly called eleuthero, and was previously marketed in the United States as Siberian Ginseng as it has similar herbal properties to those of Panax ginseng. However, it belongs to a different genus in the family Araliaceae, and it is currently illegal in the United States to market eleuthero as Siberian Ginseng since "ginseng" only refers to Panax species.
The herb grows in mixed and coniferous mountain forests, forming low undergrowth or is found in groups in thickets and edges. E. senticosus is sometimes found in oak groves at the foot of cliffs, very rarely in high forest riparian woodland. Its native habitat is East Asia, China, Japan and Russia. E. senticosus is broadly tolerant of soils, growing in sandy, loamy and heavy clay soils with acid, neutral or alkaline chemistry and including soils of low nutritional value. It can tolerate sun or dappled shade and some degree of pollution. E. senticosus is a decidious shrub growing to 2m at a slow rate. It is hardy to zone 3. It flowers in July in most habitats. The flowers are hermaphroditic and are pollinated by insects. E. senticosus is a new addition to Western natural medicine, but has quickly gained a reputation similar to that of the better known and more expensive Chinese Ginseng. Though the chemical make-up of the two herbs differs, their effects seem to be similar. The herb is an adaptogen, is anticholesteremic, is mildly anti-inflammatory, is antioxidant, and is a nervine and an immune tonic. It is useful when the hypothalamic-pituitary-adrenal axis (HPA) is depleted. Symptoms of this condition include fatigue, stress, neurasthenia and sore muscles associated with the hypofunctioning of the endocrine system, and adrenal exhaustion indicated by a quivering tongue, dark circles under the eyes, and dilating/contracting pupils. Eleuthero may alleviate these symptoms. Eleutherococcus senticosis is more tonifying than the true Ginsengs (Panax sp.). Taken regularly, it enhances immune function, decreases cortisol levels and inflammatory response, and it promotes improved cognitive and physical performance. In human studies Eleuthero has been successfully used to treat bone marrow suppression caused by chemotherapy or radiation, angina, hypercholesterolemia, and neurasthenia with headache, insomnia, and poor appetite. Eleutherococcus senticosus has been shown to have significant antidepressant effects in rats. E. senticosus contains eleutherosides, triterpenoid saponins which are lipophilic and which can fit into hormone receptors. The major constituents of E. senticosus are Ciwujianoside A-E, Eleutheroside B (Syringin), Eleutherosides A-M, Friedelin and Isofraxidin. The Siberian Ginseng Extract used in dietary supplements is derived from the roots and rootstalks of the plant Eleutherococcus senticosus. Benefits • Endurance Increasing Effects • Memory improvement Effects • Anti-inflammatory Effects • Immunogenic Effects • Chemoprotective Effects • Radiological protection • Antidepressant Effects Safety Siberian Ginseng Extract is safe; no side effects have been reported to date. Interactions and side effects People with medicated high blood pressure should consult their doctor before taking E. senticosus as it may reduce their need for medication. E. senticosus will enhance the effectiveness of mycin class antibiotics. Dosage • The typical dose is 300-900mg per day (usually in 2-3 doses throughout the day). • Consult physicians for different condition specifics.
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