Ganciclovir GCV 82410-32-0
CAS No: 82410-32-0
Molecular formula: C9H13N5O4
Molecular weight: 255.23
|Appearance: white crystalline powder||Relative matter : ≤1.0%||Limit of Guanine : ≤0.6%||Loss on dry : ≤6.0%|
|Residue on ignition : ≤0.1%||Heavy metals : ≤10ppm||Assay : 98.0%-102.0%(HPLC)|
mechanism of action:
Ganciclovir is a synthetic analogue of 2'-deoxy-guanosine. It is first phosphorylated to a deoxyguanosine triphosphate (dGTP) analogue. This competitively inhibits the incorporation of dGTP by viral DNA polymerase, resulting in the termination of elongation of viral DNA.
Absorption of the oral form is very limited - about 5% fasting, about 8% with food. It achieves a concentration in the central nervous system of about 50% of the plasma level. About 90% of plasma ganciclovir is eliminated unchanged in the urine, with a half-life of 2-6 hrs, depending on renal function (elimination takes over 24 hours in end-stage renal disease).