Oleanolic acid

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Min.Order Quantity: 1 Kilogram/Kilograms
Supply Ability: 10 Ton/Tons per Month
Payment Terms: L/C,D/A,D/P,T/T,Western Union,MoneyGram
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Quick Details

Type:
Herbal Extract
Variety:
Oleanolic acid
Form:
Powder
Part:
Seed
Extraction Type:
Liquid-Solid Extraction
Packaging:
Drum,Plastic Container
Place of Origin:
Shaanxi China (Mainland)
Grade:
1
Brand Name:
bosheng

Packaging & Delivery

Packaging Detail: 25kg/drum
Delivery Detail: 3 days

Specifications

Product: Oleanolic Acid
Plant Source: Ligustrum lucidum / snow gall
Effective Active Elements: Oleanolic
HPLC:95%; 98%

Source of Phytochemical : Randia dumetorium, Ocimum sanctum.

Pharmacology :

oleanolic acid (OA),purified components from several Botanical drugs with known antitumor activity such as, were examined for their ability and possible pathway on inhibiting the tumor growth of hepG2 cells. Cells were treated with OA and UA with doses of 100 and 200 ug/ml for 12, 24 and 36 hrs, respectively. The changes of DNA fragmentation, apoptotic bodies, DNA synthesis and the expression of cell cycle related genes were investigated after various treatments. Decrease of DNA synthesis in cells treated with both OA and UA was obviously observed at these doses for 24 and 36 hrs by using BrdU staining method. Total RNA were purified with RNA Zol B reagent and the first stranded cDNA were synthesized by AMV transcriptase. Semiquantitation of the cDNA was performed by primer dropping method. Both mRNA and protein of the CDK inhibitor of INK4 family which specifically inhibits CDK4/6 activity and then reduces the phosphorylation of RB, p-15INK4b, in hepG2 cells were greatly induced by OA and UA. However, the expression of another member in this family, p-16INK4a, was not significantly induced. Other CDK inhibitors such as p-21CIP, p-27KIP and cell cycle related genes were not induced after various OA and UA treatments. The DNA fragmentation and apoptotic bodies were also found in this study with both the time- and dose-dependent phenomena. These results suggested that the apoptosis induced by OA and UA might be partially mediated through PKC pathway and associated with p-15INK4b gene induction

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Xi'an Bosheng Biological Technology Co., Ltd., located in New Town Science and Technology Park, is devoted to biotech industry and natural botanical ingredients, integrating research and development, manufacture and sale together. We specialize in manufacturing all kinds of natural herb extracts, natural food additives, pharmaceutical intermediates, and daily chemical products, as well as in the technology research, transfer and consultation of food, drink, cosmetics, medicine and healthy ... View detail

Basic Information

Product/Service (We Sell): Ginkgo Biloba Leaf Extract,Honey Suckle Extract,Pueraria Extract,Acai Berry Extract,Dodder Extract,Common Cnidium Fruit Extract  
Number of Employees: 101 - 200 People  

Trade & Market

Main Markets: Southeast Asia
Africa
Oceania
Mid East
Eastern Asia
Western Europe
Northern Europe
Southern Europe
South Asia
Domestic Market
South America
Eastern Europe
Central America
North America
Total Annual Sales Volume: Above US$100 Million  
Export Percentage: 71% - 80%  

Factory Information

Factory Size (Sq.meters): 1,000-3,000 square meters  
Factory Location: Hanzhong Shaanxi China  
Number of Production Lines: 2  
Number of R&D Staff: 5 - 10 People  
Number of QC Staff: 5 - 10 People  
Contract Manufacturing: OEM Service Offered   Design Service Offered   Buyer Label Offered  

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China (Mainland) | Manufacturer, Trading Company | Contact Details
Experience: Established 2009

Communicate with Supplier:

Mr. zhihui Zhang
Mr. zhihui Zhang:
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