S-Adenosyl-L-methionine Powder 99% (SAMe) Ademetionine

FOB Price: US $450 - 600 / Kilogram Get Latest Price
Min.Order Quantity: 1 Kilogram/Kilograms
Supply Ability: 750 Kilogram/Kilograms per Month
Port: Shanghai
Payment Terms: L/C,D/A,D/P,T/T,Western Union,MoneyGram,Paypal
Add to My Favorites

Quick Details

CAS No.:
29908-03-0
Other Names:
SAMe(S-Adenosyl-L-Methionine Disulfate Tosylat)
MF:
C15H23N6O5S
EINECS No.:
249-946-8
Place of Origin:
Shaanxi China (Mainland)
Type:
Electrolyte Balance and Dialysis Agents
Grade Standard:
Food Grade,Medicine Grade
Brand Name:
Realin
Model Number:
Rl170649
Purity:
99%
Appearance:
White powder
Specification:
99%
MOQ:
1 KG
Mesh size:
80 mesh
Standard:
In house,USP,JP,EP,BP
Package:
drum and foil bag,or required by clients
Shelf life:
2 years when properly stored
Storage:
preserve in tightly sealed,light and oxygen resistant containers
EINECS:
249-946-8

Packaging & Delivery

Packaging Detail: 25kg carton drum (38cm*50cm)or 1kg foil bag (21cm*31cm) or by request of clients
Delivery Detail: prompt delivery after payment confirmed by air courier or by sea

Specifications

-Natural S-Adenosyl-L-methionine(SAMe)
-CAS No.29908-03-0
-White crystalline powder
-ISO9001:2008,GMP certified

 

 

 High Quality GMP Standard S-Adenosyl-L-methionine (SAMe)

 

 

SAMe

 

 S-Adenosyl-l-methionine Disulfate Tosylate (SAMe for short) is a common cosubstrate involved in methyl group transfers. SAM was first discovered in Italy by G. L. Cantoni in 1952, can preventing liver cancer, promoting cartilaginous tissue forming and concrescence, may help fight depression, alzheimer's disease, liver disease, and the pain of osteoarthritis, is now universerally acknowleged as an important pharmaceuticals to treat liver diseases. Nowaday it is commonly used in pharmaceuticals, health care food industry both at domestic and international market.

  

 

  

Appearance

Almost white crystal/powder,hygroscopic

Consistent

Identification

(IR)

Positive

Water content (K.F.)

2.0% max

1.38%

Solubility

Soluble in water

Consistent

PH (so 1.5)

1.0-2.0

1.29

Ademethionine ion (HPLC)

40.0%min (as anhydrous)

44.52%

(S,S-Enantiomers)

60%min (as area%)

79.30%

p-Toluenesulfonic acid (HPLC)

21-24% (as anhydrous)

32.51%

Sulfates

23.5-26.5% (as anhydrous)

22.20%

Purity(HPLC)

95%min

99.23%

Related Substances(HPLC)

The sum area of unknown impurities must be not more than 1.5 times of reference solution main peak’s (1.5%)

0.10%

Adenosine

0.5%max (as area%)

0.04%

Methylthioadenosine

1.5%max (as area%)

0.47%

S-Adenosyl-L-Homocystsine

0.5%max (as area%)

0.01%

Heavy metals

10ppm

Consistent

E.coli

Negative

Consistent

Salmonella

Negative

Consistent

Sulphated ash

0.5%max

0.16%

Microbiological

1000CFU/g max

23CFU/g

CONCLUSION:  The results of all the analysis items are up to standard

 

 

 

 

Product name

Natural S-Adenosyl-L-methionine (SAMe)

Appearance

White crystalline powder

CAS No.

29908-03-0

EINECS

249-946-8

Molecular weight

398.44

Purity

99%min

E.coli

Negative

Salmonella

Negative

Extraction type

Solvent extraction

Grade

Pharmaceutical and food

Storage

Stored in a clean, cool, dry area; keep away from strong, direct light.    

Shelf life 

2 years when properly stored.  

Package

1kg/bag,25kg/drum.Or it's at your option .

Delivery

Within 3-5 days after payment. 

 

Function

    1.Natural SAMe is a good nutrition for the liver,can prevent alcohol, drugs and the liver-cell injury;

    2.Natural SAMe has remarkable preventive effects on chronic active hepatitis, and other factors caused liver injury,heart disease, cancer and so on.

    3.Natural SAMe has been found to be as effective as pharmaceutical treatments for arthritis and major depression as well.

High Quality, Competitive Price, Best Service

 

 

Product Name:  SAMe(S-Adenosyl-L-Methionine Disulfate Tosylat)

 

CAS: 29908-03-0

 

Purity:  99%

 

Product Name:

SAMe(S-Adenosyl-L-Methionine Disulfate Tosylat)

Appearance:

White crystalline powder

CAS No.:

29908-03-0

Molecular Weight:

399.4448

Molecular Formula:

C15H23N6O5S

Supplier name:

xi’an Realin biotech co.,ltd

Specification:

99%

Structure:

 

Function:

 

1 S-Adenosyl methionine (SAM, SAMe, SAM-e) is a coenzyme involved in methyl group transfers. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase (EC 2.5.1.6). Transmethylation, transsulfuration, and aminopropylation are the metabolic pathways that use SAM. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver.

 

2 The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive. This allows donation of this group to an acceptor substrate in transmethylation reactions. More than 40 metabolic reactions involve the transfer of a methyl group from SAM to various substrates such as nucleic acids, proteins, and lipids.

 

3 In bacteria, SAM is bound by the SAM riboswitch, which regulates genes involved in methionine or cysteine biosynthesis.

The reactions that produce, consume, and regenerate SAM are called the SAM cycle. In the first step of this cycle, the SAM-dependent methylases (EC 2.1.1) that use SAM as a substrate produce S-adenosyl homocysteine as a product.This is hydrolysed to homocysteine and adenosine by S-adenosylhomocysteine hydrolase EC 3.3.1.1 and the homocysteine recycled back to methionine through transfer of a methyl group from 5-methyltetrahydrofolate, by one of the two classes of methionine synthases (EC 2.1.1.13 or EC 2.1.1.14). This methionine can then be converted back to SAM, completing the cycle.

 

4 Another major role of SAM is in polyamine biosynthesis. Here, SAM is decarboxylated by adenosylmethionine decarboxylase (EC 4.1.1.50) to form S-adenosyl-5'-3-methylpropylamine. This compound then donates its n-propylamine group in the biosynthesis of polyamines such as spermidine and spermine from putrescine.

 

5 SAM is required for cellular growth and repair. It is also involved in the biosynthesis of several hormones and neurotransmitters that affect mood, such as dopamine and serotonin. Methyltransferases are also responsible for the addition of methyl groups to the 2' hydroxyls of the first and second nucleotides next to the 5' cap in messenger RNA.

6 In the United States, SAM is sold as a nutritional supplement under the marketing name SAM-e (also spelled SAME or SAMe). Some research has indicated that taking SAM on a regular basis help fight depression, liver disease, and the pain of osteoarthritis. Multiple clinical trials indicate benefits for depression, some liver conditions and osteoarthritis. All other indications are not yet proven.

Delivery Time:

Within 2 days

Packaging Detail:

Sealed export grade drum & double of sealed plastic bag

Storage:

Store in cool & dry place not freeze. keep away from strong light and heat

Shelf life:

2 years when properly stored

 

 

 

 

 

Shipping

 

 

 

 

Not exactly what you want? 1 request,multiple quotations Get Quotations Now >>
Xi'an Realin Biotechnology Co., Ltd. was founded in 2002. We focus on designing, researching and developing, manufacturing and selling plant extract and chemical products. We have more than 200 self-developed designs and molds for you to choose from. We release at least 8 new products monthly to meet the latest markets' needs. With our rich experience and considerate services, we have been recognized as a reliable supplier for many international buyers. We operate our in-house facilities to ... View detail

Basic Information

Product/Service (We Sell): Lycopene,Astaxanthin,Soy isoflavones,SAM-e,Loniten  
Number of Employees: 51 - 100 People  

Trade & Market

Main Markets: South Asia
Eastern Asia
Mid East
Africa
Southeast Asia
Eastern Europe
South America
North America
Total Annual Sales Volume: US$2.5 Million - US$5 Million  

Factory Information

Number of R&D Staff: 5 - 10 People  
Number of QC Staff: 5 - 10 People  

Supplier Assessment Report

Do you want to know more about this company before you make a deal? Request an Assessment Report.
Supplier Assessment Reports are detailed on-line reports about the supplier's capabilities. It helps you get all the information you need to trade confidently with suppliers.

Send your message to this supplier

Sourcing Products & Suppliers on Alibaba.com

Search Products
Enter the product you are looking for in the Search Bar and click Search
Contact Suppliers
Click Contact Now to send an inquiry or I’m online, Chat now to chat online
Check Messages
Check quotes & messages from suppliers in your email inbox or Message Center
China (Mainland) | Manufacturer, Trading Company | Contact Details
Experience: Established 2012

Communicate with Supplier:

Ms. Julie Li
Ms. Julie Li:
What can I do for you?
Not exactly what you want?
1 request,multiple quotations Get Quotations Now >>
You May Like: