grape seed extract proantocyanidins 95%

FOB Price: US $20 - 50 / Kilogram | Get Latest Price
Min.Order Quantity: 25 Kilogram/Kilograms
Supply Ability: 5 Ton/Tons per Month
Port: shanghai,changsha
Payment Terms: L/C,T/T,Western Union
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Quick Details

Grape Seed Extract
Extraction Type:
Solvent Extraction
Place of Origin:
Hunan, China (Mainland)
food supplement
Brand Name:
yuanhang biology
Model Number:
grape seed extract
95% Proantocyanidins(OPC), 80%,90% Polyphenols.UV-VIS

Packaging & Delivery

Packaging Details: Pack in cardboard drums and two polyethylene bags inside. NW:25kg/drum,GW:28kg/drum. Store in a well-closed container away from direct sun light and moisture.
Delivery Detail: 7 days after order
Company Information











ISO9001:2008, ISO22000:2005, HACCP,KOSHER.






Product Description



grape seed extract  

spec:proanthocyanidins 95%polyphenols 80%,90%,UV



Vitis vinifera (Common Grape Vine) is a species of Vitis, native to the Mediterranean region, central Europe,

and southwestern Asia, from Morocco and Spain north to southern Germany and east to
northern Iran. It is a liana growing to 35 m tall, with flaky bark. The leaves
are alternate, palmately lobed, 5–20 cm long and broad. The fruit is a berry,
known as a grape; in the wild species it is 6 mm diameter and ripens dark purple
to blackish with a pale wax bloom; in cultivated plants it is usually much
larger, up to 3 cm long, and can be green, red, or purple. The species typically
occurs in humid forests and streamsides.

Oligomeric proanthocyanidins (OPCs) are some of the most abundant polyphenolic substances in the plant
kingdom. Proanthocyanidins are an integral part of the human diet, found in high
concentrations in fruits such as apple, pear, and grapes, and in chocolate,
wine, and tea. OPCs in nutritional supplements are generally extracted from
grape seeds or pine bark. Due to potent antioxidant activity, OPCs have been the
subject of recent research, demonstrating anticarcinogenic, anti-inflammatory,
antimicrobial, and vasodilatory properties, making them a potentially valuable
therapeutic tool for the treatment of a variety of conditions.

The Grape Seed Extract used in dietary supplements is derived from the seeds of the plant
grape(Vitis vinifera L.).

• Anti-oxidant activity
• Anticarcinogenic activity
• Anti-imflamatory and antimicrobial
• Vasodilatory

OPCs possess antioxidant, antimutagenic, anticarcinogenic, anti-inflammatory, and
antiviral properties.

The potent antioxidative properties of OPCs account for their therapeutic benefit in disease states
characterized by oxidative stress. OPCs also demonstrate potent,
concentration-dependent, free radical scavenging ability. (9) Studies in mice
show OPCs inhibit chemically-induced lipid peroxidation, DNA fragmentation, and
subsequent apoptosis (indicators of oxidative tissue damage) in a dose-dependent
manner in hepatic and brain tissue. (10) Human studies also demonstrate an
antioxidative mechanism as evidenced by decreased lipid peroxidation of LDL
cholesterol (11,12) and increased free-radical trapping capacity after
consumption of red wine containing OPCs. (7)

OPCs appear to have an affinity for vascular tissue and strongly inhibit several enzymes involved in
degradation of collagen, elastin, and hyaluronic acid, the main structural
components of the extravascular matrix. (13) These effects are perhaps
attributable to trapping reactive oxygen species and preventing oxidative injury
to vascular endothelium. In vitro studies have also found OPCs increase
resistance of cell membranes to injury and degradation.

Proanthocyanidins possess endothelium-dependent relaxing (EDR)
activity in blood vessels by increasing nitric oxide production, (16) and
stimulate vascular endothelial growth factor, a signaling factor involved in
initiation of wound healing. OPCs may also protect the microvasculature of the
retina and increase visual acuity, possibly by increasing the rate of rhodopsin
regeneration. (17-19) In a rabbit model of ischemia/ reperfusion, OPCs'
beneficial effects were attributed to binding of copper and iron liberated from
myocardial tissue, thereby reducing their oxidative effects. (20) The positive
effects of OPCs on microcirculation are also attributed to their inhibition of
LDL oxidation. (11,12,21) and decreased incidence of foam cells, markers of
early stage atherosclerosis. (22) Grape seed proanthocyanidins may have a
vitamin E-sparing effect. (23) A clinical study of 10 healthy volunteers
examining the effect of OPC supplementation on markers of oxidative stress
showed significantly increased levels of alpha-tocopherol in red cell membranes.

OPCs from pine bark decrease symptoms of
chronic inflammation. In vitro studies demonstrate anti-inflammatory effects may
be due to inhibition of peroxide generation by macrophages. (25,26) In addition,
animal studies demonstrate OPCs from grape seed significantly inhibit formation
of proinflammatory cytokines, interleukin 1-beta, and tumor necrosis
factor-alpha. (27)

OPCs possess
natural antimutagenic properties when exposed to certain strains of bacteria.
(28) Although the exact mechanism is not known, an in vitro study found OPCs
exhibit selective cytotoxicity for certain cancerous cell lines, while remaining
non-toxic to normal human gastric mucosal cells and macrophages. (29) An in
vitro study in a mouse skin tumor model demonstrated OPCs' inhibition of two
markers of tumor promotion. (30)

Grape Seed Extract is safe.






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Hunan Yuanhang Biological Technology Products Co., Ltd. is a high-tech manufacturer founded in 2004 with the investment of USD5 million. As the pioneer botanical extract manufacturer and supplier in China, our company has established new and effective methods to purify and concentrate herbs and their active compounds. We are also authorized self-management import and export rights. Our main products include herbal extract, medicine intermediate and traditional medicine formula. Our annual pro... View detail

Basic Information

Business Type: Manufacturer, Trading Company  
Main Products: plant extract,honeysuckle flower extract,eucommia leaf extract,red clover extract,green tea extract  
Number Of Employees: 51 - 100 People  

Trade & Market

Main Markets: South Asia
Southern Europe
Northern Europe
Southeast Asia
Central America
Western Europe
North America
Eastern Asia
Eastern Europe
Total Annual Sales Volume: US$5 Million - US$10 Million  
Export Percentage: 31% - 40%  
Trade Shows: Supplyside West    

Factory Information

Factory Size (Sq.meters): 3,000-5,000 square meters  
Factory Location: No.78 Taijia Road,Wangcheng Economic Development Zone,Changsha, 410200,Hunan,China  
No. of Production Lines: 4  
Number of R&D Staff: 5 - 10 People  
Number of QC Staff: 5 - 10 People  
Certifications: ISO9001,ISO14001,HACCP
Contract Manufacturing: OEM Service Offered   Design Service Offered   Buyer Label Offered  

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How It Works

China (Mainland) | Manufacturer, Trading Company | Contact Details
Experience: Established 2004 , 10 years OEM

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