herbal polygala vulgaris extract(milkwort extract;natural medicine).

herbal polygala vugaris  root extract have Cytotoxic Compounds  and Polygalaceae are known to contain a variety of different polyphenolic compounds such as xanthones, flavonoids, and biphenyl derivatives.

Fractionation of the active extracts led to the isolation of three new compounds, a derivative of aucuparine and two xanthones, as well as a known methylsinapate. All compounds were tested for in vitro cytotoxic activity using two cell lines, LoVo and its strain, which express resistance to common antitumor agents.

USED : It used as  emetic and cathartic; in ordinary doses, it stimulates most of the secretions, acting especially as a sialagogue, expectorant, diuretic, diaphoretic, and emmenagogue. Its expectorant properties render it very useful in chronic catarrh, and protracted and typhoid pneumonia, bronchorrhoea, chronic bronchitis, with profuse secretion, humoral asthma, and in the commencing stages of croup. In active inflammation its use is contraindicated. In relaxed sore throat, it is recommended as a, local stimulant; also as a diaphoretico-diuretic in rheumatism, and as an emmenagogue in amenorrhoea. It is not without effect upon squamous skin diseases, and its action in this direction should be studied. Dose of the powdered root, from 5 to 20 grains; of the infusion or syrup, from 1/2 to 2 fluid ounces. The extract prepared from an infusion of the root, obtained by percolation, and evaporated to the proper consistence by means of a water-bath, may be given in doses of from 1 to 4 grains; specific Senega, 1 to 20 drops. Polygalic acid may be given for the same purposes as the root, in doses of from 1/4 to 1/2 grain. It is best taken in hot, sweetened water.