It is indicated for the prevention and treatment of vitamin B₆ deficiency and isoniazid poisoning, and also for vomiting and seborrhoic dermatitis etc caused by pregnancy, radiation diseases and anticancer drugs.

Total parenteral alimentation and Vitamin B₆ supplement during malnutrition and progressive weight loss due to insufficient intake.

The requirements for vitamin B₆ are increased under the circumstances below: pregnancy and lactation, hyperthyroidism, burn, persistent chronic infection, fever, congenital dysbolism (cystathioninuria, hyperoxaluria, homocystinuria, xanthurenic aciduria), congestive cardiac failure, chronic hemodialysis, malabsorption syndrome complicated with hepato-biliary diseases (e.g. alcoholic poisoning complicated with cirrhosis), intestinal tract diseases (celiac syndrome, tropical sprue, persistent diarrhea) and postgastrectomy.

 Hereditary vitamin B₆ dependence syndrome in newborns.