Eulipid^TM is an innovative formulation made up of Berberine from Berberis Aristata, Bioflavonoids from Citrus Aurantium and Policosanols from Oryza Sativa with Resveratrol from Polygonum Cuspidatum, Tocotrienols from Elaeis Guineensis Jacq. and Q10 Coenzyme.

The research demonstrates that these components, in integration with a proper diet, can contribute in a favorable way to restore the physiological equilibrium of hematic levels of total cholesterol, LDL cholesterol and triglycerides.

Mechanism of action

• Berberine reduces LDL cholesterol, triglycerides and total cholesterol plasmatic levels throughout the increase of liver clearance. Berberine has a distinct mechanism of action from statins that instead inhibits HMG-CoA reductase. Moreover Berberine enhances glucose transport inside cells reducing iperglicemia.
• Bioflavonoids, tocotrienols and polycosanols enhance ipocholesterolemic action of Berberine.
• Antioxidant complex (Bioflavonoids, Resveratrol, Alfa lipoic acid, Coenzyme Q10, Vitamin E and Piperine) inhibits LDL oxidation and stabilizes atherosclerotic plaque.

Nutritional properties assigned from the scientific literature.

Berberine⁽¹⁾: Berberine is one of the main alkaloids presents in plants of the Berberis family. In various scientific studies Berberine has demonstrated to be a useful complement in the treatment of the dislipidemiae, favouring a meaningful reduction of the hematic levels of triglycerides, LDL and total cholesterol. Berberine can be of aid in the prevention of the insurgence of the atherosclerotic plaques thanks to its anti-oxidant and anti-inflammatory action on the smooth vessel muscular cells. Supplementation with Berberine is a valid adjuvant in the treatment of patients with congenital cardiac insufficiency according to its positive antiarrhythmic and inotropic effect.

Bioflavonoids⁽²⁾: Bioflavonoids polymethoxylated flavonoids (PMF) - are a subclasses of Citrus flavonoids,that have been studied for their anti-inflammatory and hypolipidemic properties. Besides the anti-oxidant action, scientific studies have evidenced the ability of the polymethoxylated flavonoids to inhibit the hepatic synthesis of cholesterol and triglycerides. Recent studies have demonstrated that the PMF act in synergy with tocotrienols in the control of the hematic cholesterol and triglycerides levels.

Policosanols: Policosanols are a natural mixture of aliphatic primary alcohol extracted from the wax of rice or of sugar cane.

Policosanols improve the hematic lipid profile, reducing the hepatic biosynthesis of cholesterol and increasing the clearance of cholesterol LDL. They reduce, moreover, the lipids oxidation, the platelet aggregation and the proliferation of the endothelial smooth muscular cells contrasting thereby the insurgence of cardiovascular diseases.

Resveratrol⁽³⁾: Resveratrol is a compound with powerful antioxidant properties belonging to the polyphenols class to which are assigned important properties opposing the cell aging processes. Resveratrol, contained also in red vine, protects the endothelial cells from oxidative stress caused by the LDL oxidation. Resveratrol exerts both anti-inflammatory action (through

inhibition of the cyclooxygenase enzyme COX and reduction of the synthesis of pro-inflammatory prostaglandins) and vessel-protecting actions (through the increase of the nitric oxide production and the reduced expression of vasoactive peptides), showing a marked effectiveness in the cardiovascular protection. To Resveratrol is imputed the merit in the explanation of the so-called French paradox: the French, despite a diet rich in saturated fats, but including also a regular assumption of red vine, enjoy better cardiovascular health compared to other populations assuming comparable saturated fat quantities (American, English, German etc.).

Tocotrienols⁽²⁾: Tocotrienols are components chimically similar to tocopherols but with a higher antioxidant and antinflammatory activity. Tocotrienols act sinergically with Bioflavonoids, in the reduction of LDL cholesterol and triglycerides (through inhibition of HMG-CoA reductase activity), and with alpha lipoic acids in the prevention of the oxidative stress, giving further support to the cardioprotective properties of this component.

Coenzyme Q10: Coenzyme Q10 is found in the mitochondria of all cells. It functions as part of the cellular system that generates energy from oxygen (in the form of ATP) for bodily processes. Coenzyme Q10 promotes the conversion of the nutrients introduced through the diet in an energy form easily available to the cells. Coenzyme Q10, thanks to its antioxidant properties, has also a further protective action towards aging processes, favouring the cell membranes integrity and optimizing cell energy production. Through its role in ATP synthesis, Coenzyme Q10 may improve heart muscle function increasing its contraction strength in patients with chronic heart failures.

Alpha-lipoic Acid (ALA)⁽⁴⁾: Alpha-lipoic Acid is a natural component with a detached anti-oxidant activity. It contrasts the formation of reactive oxygen species (ROS), repairs oxidized proteins and regenerates other anti-oxidants, both exogenous than endogenous as the glutathione, Vitamin C and D (with which it acts in synergy). Recent scientific studies have evidenced the positive effect of integration with ALA in the prevention of cardiovascular

diseases, thanks to the ability of ALA to modify the hematic lipid profile and to contrast the LDL oxidation, the increase in the arterial pressure and the formation of the atherosclerotic plaques through anti-oxidant and anti-inflammatory mechanism (for inhibition of the TNF-alpha and the monocytes activation at the endothelium level).

Piperine: Piperine has not only antioxidant properties but it is also a bioavailability enhancer for therapeutic compounds. Indeed Piperine is able to improve the plasma levels of orally supplemented Coenzyme Q10, producing a significant, approx. 30% greater, increase of its bioavailability.

1. Cicero AF, Rovati LC, Setnikar I. Eulipidemic effects of berberine administered alone or in combination with other natural cholesterol-lowering agents. A single-blind clinical investigation. Arzneimittelforschung, 2007.

2. Roza J.M. et al., Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects. Alt. Therapies, 2007.

3. Baxter RA. Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation. J Cosmet Dermatol., 2008.

4. Wollin SD, Jones PJ. Alpha-lipoic acid and cardiovascular disease. J Nutr., 2003.