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High Quality Pomegranate Extract Urolithin A CAS 1143-70-0 Urolithin B

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    $18.00
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    $14.00
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    $9.50
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Overview
Quick Details
Form:
Powder
Part:
Bark
Extraction Type:
Solvent Extraction
Packaging:
Bottle, Drum, Plastic Container
Place of Origin:
China
Grade:
Pharmaceutical grade
Brand Name:
HHD, HHDPHARM
Model Number:
Pomegranate Extract Urolithin A, hhdpharm
Grade Standard:
Medicine Grade, Tech Grade
Standard:
USP/BP/CP
Assay Test Method:
HPLC
Shelf life:
2 Years properly stored
CAS:
34157-83-0
Name:
Pomegranate Extract Urolithin A
Latin Name:
Pomegranate Extract Urolithin A
Active Ingredient:
Urolithin A
Type:
Pomegranate Extract Urolithin A

Packaging & Delivery

Selling Units:
Single item
Single package size: 
1X10X20 cm
Single gross weight:
0.002 kg
Package Type:
ON REQUEST
Lead Time :
Quantity(Grams) 1 - 100 >100
Est. Time(days) 7 To be negotiated
Product Description

high quality Pomegranate Extract Urolithin A cas1143-70-0

Product Urolithin A

Brand Nutrabioteh

3,8-dihydroxy-6H-dibenzo(b,d)pyran-6-one
CAS:1143-70-0

MF C13H8O4

EINECS 1592732-453-0


Product information

high quality Pomegranate Extract Urolithin A cas1143-70-0

Urolithin A is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria.[1] It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. Its precursors – ellagic acids and ellagitannins – are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts.[2] Since the 2000s, urolithin A has been subject of preliminary studies regarding its possible biological effects.

Urolithin A is not known to be found in any food source. Its bioavailability mostly depends on individual microbiota composition, as only some bacteria are able to convert ellagitannins into urolithins.


Urolithins are microflora human metabolites of dietary ellagic acid derivatives[1] such as ellagitannins. They are produced in the human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as pomegranate,[2] strawberries, red raspberries, walnuts or oak-aged red wine.[3]

During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown biological activity in vivo in humans.[2][4] Urolithins metabolites of pomegranate juice ellagitannins localize specifically in the prostate gland, colon, and intestinal tissues of mice.[5]

Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites. Urolithins are found in plasma mostly as glucuronides at low concentrations.[6]

Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella.[7]

Function

Effect of urolithin A on cell proliferation, metastasis, and MMP‐9 activity. SW620 cells were treated with 0 (a) 0.15 (b) 1.5 (c) or 15 (d) µM urolithin A for 24 h (A) and cell proliferation was measured using MTT assay (B). Photographs (×100 magnification) are representative of three independent experiments. Cell monolayers were wounded using 200 µL pipette tips, treated with 0 (a) 0.05 (b) µM urolithin A for 48 h and photographs were taken (×100 magnification) to measure cell migration (C). After treatment with 0 (a) 0.05 (b) µM urolithin A for 48 h, cells were seeded above transwell chamber membranes. After 4 h, membrane bottoms were stained with crystal violet and photographs were taken (×200 magnification) to assess cell invasion (D). MMP‐9 activity was determined by MMP assay in cells treated with 0.05 µM urolithin A for 48 h (E) *P < 0.05 represents significant difference from the control group

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Company Introduction
Wuhan Hengheda Pharm Co., Ltd. is a hi-tech enterprise located in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. Hengheda Pharm has complete administration management and a good work team, which makes us grow fast in chemicals and pharmaceutical industry.Hengheda Pharm has a novel R&D center with advanced ventilation equipment and modern experiment equipment. We offer friendly working environment and have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of these make us provide good quality products with high rating.Hengheda Pharm follows the principle of "quality first, customer above and credit fundamentality", wishing to offer the best products to our customers.
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