Melatonin is a hormone made from the pineal gland that activates the melatonin receptor. Melatonin plays a role in sleep and has important antioxidant and anti-inflammatory properties.
In vivo studies
Melatonin increased the levels of activated PTEN, rsk-1, mTOR and AMPK α kinases, mildly inhibited erk-1 / 2 phosphorylation and dephosphorylation, significantly inhibited the phosphorylation of S6 ribosomal protein, 4E-BP1, GSK-3 α and GSK-3 β, and slightly increased the phosphorylation of pras40 in animals . Melatonin improves neurotoxicity and astrocyte activation induced by a β 1-42 in cerebral cortex. Melatonin also blocked a β 1-42 induced reduction in the expression of Reelin and Dab1 . Melatonin treatment and NLRP3 - / - deficiency have similar inhibitory effects on NF - κ B and NLRP3 signaling pathways in mice. Melatonin treatment and NLRP3 - / - deficiency share some clock gene expression patterns and improve cardiomyocyte morphology in mice .
Preparation of melatonin
1. Melatonin exists in the pineal gland of mammalian brain. Generally, bovine pineal gland is freeze-dried and grinded into powder. The fat is removed by petroleum ether and mixed with deionized water to form a slurry. After centrifugation, the supernatant is taken and extracted with equal volume of ethyl acetate. After vacuum drying, the crude product of melatonin is obtained and recrystallized Get the best.
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