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Wuhan HHD Nootropic Manufacturer High Quality 7,8-DHF/7,8-dihydroxyflavone CAS 38183-03-8 free sample

  • 10-99 Grams
    $5.00
  • 100-999 Grams
    $3.80
  • >=1000 Grams
    $3.15
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Lead Time:
7 day(s) after payment received
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Customized packaging (Min. Order: 10000 Grams)

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Quick Details
CAS No.:
38183-03-8
Other Names:
7 8-DHF
MF:
C19H23N3O3
EINECS No.:
n/a
Place of Origin:
China
Type:
Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity:
99%
Brand Name:
HHD-PHARM, HHDPHARM
Model Number:
HHD-PHARM, hhdpharm
Application:
pharmaceutical raw material
Appearance:
white crystal powder
Grade Standard:
Medicine Grade, Tech Grade
Standard:
USP/BP/CP
Stability:
Stable
Target Market:
Worldwide
Assay Test Method:
HPLC
Shelf life:
2 Years properly stored
Stock availability:
Large stock
Manufacturer:
Wuhan Hengheda Pharm

Packaging & Delivery

Selling Units:
Single item
Single package size: 
30X20X20 cm
Single gross weight:
0.001 kg
Package Type:
ON REQUEST
Lead Time :
Quantity(Grams) 1 - 1000 >1000
Est. Time(days) 7 To be negotiated
Wuhan HHD Nootropic manufacturer high quality 7,8-DHF/7,8-dihydroxyflavone CAS 38183-03-8 free sample
Product Description
Wuhan HHD Nootropic manufacturer high quality 7,8-DHF/7,8-dihydroxyflavone CAS 38183-03-8 free sample

Product Name: 7,8-dihydroxyflavone

Other name:7,8-DHF

Molecular Formula: C15H10O4

CAS No.: 38183-03-8

Appearance: Yellosw powder

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).


7,8-DHF is both orally bioavailable and able to penetrate the blood–brain barrier. A prodrug of 7,8-DHF with greatly improved potency and pharmacokinetics, R7, is under development for the treatment of Alzheimer's disease.

·

7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome.

 

7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents.

 

In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity.

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Company Introduction
Wuhan Hengheda Pharm Co., Ltd. is a hi-tech enterprise located in Wuhan Private Science and Technology Park, specializing in custom synthesis, manufacture and import & export of fine chemicals, APIs and pharmaceutical intermediates. Hengheda Pharm has complete administration management and a good work team, which makes us grow fast in chemicals and pharmaceutical industry.Hengheda Pharm has a novel R&D center with advanced ventilation equipment and modern experiment equipment. We offer friendly working environment and have skilled people with rich experience in various kinds of experiments and talent chemists professional in R&D and QC. All of these make us provide good quality products with high rating.Hengheda Pharm follows the principle of "quality first, customer above and credit fundamentality", wishing to offer the best products to our customers.
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